Ivermectin Dosage Calculator
This information is NOT medical advise!
It is data gathered from various sources and presented here for your use.
Please use the Contact Me link if you find data that is incorrect.
Enter your weight in pounds in the yellow box. Then click (or tap) on the calculate button.
There are predominantly two dosage ratios (200mcg/kg and 400mcg/kg) mentioned in many papers3, 18, 43
The aggressive dose may be administered orally once per day for 4 days. The first daily dose will put a percentage of the peak level of that dose into your system within a few minutes. The level in your system will then decline. At about 18 hours the level in your system will decline to 50% of the peak dose, and will continue to decline until you take the next dose.
When you take the next dose, the same effect happens, but this time the peak dose will be added to the residual that is left in your system from the previous dose(s). This same thing will happen after each dose.
The limit of the peaks will be reached after the 4th dose, which should be your last dose of the "agressive" dosage.
Drug Half-Life Calculator
Following is a Half-Life Calculator where you can enter your calculated dose (from above). Enter the half-life of Ivermectin (18 hours). Enter how often you wish to take the dose (agressive = every 24 hours, prophylactic = 168 hours).
Global input
Half-life:
If taken regularly
Time between doses:
Stabilized daily min–max (sum of residuals):
To ramp up to maximum level (within the percentage above):
Ramp up details
To ramp back down from maximum (within the percentage above):
If taken once
Time for one isolated dose to drop within the percentage above:
Level after 24 hours, for one isolated dose:
Sources of Ivermectin
DurvetImage The brand I use
Sold at Tractor Supply
I purchased the 250ml bottle for $79.99 and expect it to last at least a year.
That puts my cost at $0.32 USD per ml. or $0.64 USD per dose for my weight.
Noromectrin (Green Label)I do NOT recommended this product for human consumption!
I believe the Clorsulon in this product represents a significant danger to those who have any sensitivity to sulfonamide drugs.
I am still researching this product. I will update as I gather information.
This product is sold at my local MFA
Sourced from India company
Ivermectin Tablet - Uses, Side Effects, Composition & Price This is a website in India with info that can be used to comparison shop.
Shop around and you can find IVM (Ivermectin) as low as $.02 USD per 12mg tablet.
Update: Contacted supplier in India and the cost for 1 box (200 12mg tablets) with shipping and customs would be $89.00 USD. That's more than my per dose cost.
Information About Ivermectin
CDC says it should be used for scabies and worms.1
May shorten duration of Covid-19.2 , 6
May participate in the war against cancers (prostate, breast, ovarian, leukemia)3, 55 In vitro and in vivo antitumor activities of ivermectin.4
Ivermectin-induced drug reaction5, 6
Associated with lower Covid-19 mortality.7
A new tool to eliminate malaria?27 A possible weapon against West Nile Virus?26
Nobel prizes awarded for discovery and practical use of Ivermectin. 12, 40
South Carolina Dept. of Health tries to bury the truth of Ivermectin. 39
2023 study finds IVM not effective as COVID treatment45
2019 FDA approved 1% Ivermectin for treatment of rosacea in adults.53, 54,
2024 Ivermectin shows promise of improved Covid survival rates.56
2024 Ivermectin may have therapeutic benefits for IPF.58
2021 Ivermectin is known to inhibit the replication of flavivirus.61
2019 Significant reduction in bed bug population after insects feed on blood of person that has taken only 1 dose of Ivermectin.62
Experiences with Ivermectin
Personal
After the first dose, I experienced slight symptoms of vertigo and a short period (about an hour) of very slightly blurred vision (not anywhere near like removing my glasses).
Dose 2, 3 and 4 on days 2, 3 and 4, each precipitated similar vertigo symptoms, although with shorter and less intense symptoms each successive day.
My 5th dose was taken 168 hours (1 week) after number 4 dose and there were no side effects experienced.
Dose #6 was taken 168 hours after dose #5. No side effects noted.
Case studies
Report of DRESS symptoms5
References:
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Added Sept. 29 2023:
2006 Mar: A case of crusted scabies with a bullous pemphigoid-like eruption and nail involvement
Case Study: Patient was diagnosed as having crusted scabies with bullous pemphigoid-like eruptions and nail involvement
prescribed oral ivermectin (two doses of 12 mg ivermectin with a 1-week interval) and topical lindane (1%gamma-BHC in petrolatum) for scabies with 5% salicylic acid in plastibase as an additional treatment for the crusted lesions on his soles. He showed remarkable improvement in 2 weeks, and his nails showed complete recovery after 7 weeks of occlusive dressing treatment with 1%gamma-BHC.
The bullous symptoms of this patient were considered to be due to the scabies, because the patient recovered completely after receiving treatment for scabies. Indirect immunofluorescent study is important to distinguish between scabies with blister formation and true bullous pemphigoid.
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Added Sept. 29 2023: Updated Oct. 2 2023
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Added Sept. 29 2023:
Ivermectin-induced drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome
Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome, also known as drug-induced hypersensitivity syndrome, is a rare, potentially life-threatening adverse drug reaction with an estimated mortality rate up to 10%.
These adverse reactions occur within 7 days of the administration of ivermectin and are likely related to the intensity of the filarial (parasite) infection and the release of parasite antigen. Since the eosinophil storm is likely caused by the dying parasites causing an avalanch of lymphosites, is this where control points should be established?
Might the Mazzotti effect also be triggered by large populations of bacteri and viruses?
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Added Sept. 29 2023:
2012 Ivermectin Inhibits Growth of Chlamydia trachomatis in Epithelial Cells
Here we show that ivermectin also inhibits infection of epithelial cells by the bacterial pathogen, Chlamydia trachomatis, at doses that could be envisioned clinically for sexually-transmitted or ocular infections by Chlamydia.
For use in humans as an anti-helminthic, ivermectin is typically received orally at a dose of 150 µg/kg body weight, and peak plasma concentrations from such dosage reach around 60 nM
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1996 Ivermectin distribution in the plasma and tissues of patients infected with Onchocerca volvulus
The plasma levels for patients, after 5.2 hours, peaked at 52.0 ng/ml. The elimination half life was 35.0 h;
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Added Sept. 29 2023:
2023 Pharmacokinetics of ivermectin metabolites and their activity against Anopheles stephensi mosquitoes
Survival of malaria transmitting Anopheles mosquitoes is strongly decreased after feeding on humans recently treated with ivermectin. Currently, mass drug administration of ivermectin is under investigation as a potential novel malaria vector control tool to reduce Plasmodium transmission by mosquitoes. A "post-ivermectin effect" has also been reported, in which the survival of mosquitoes remains reduced even after ivermectin is no longer detectable in blood meals.
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2017 Ivermectin to reduce malaria transmission I. Pharmacokinetic and pharmacodynamic considerations regarding efficacy and safety
A fancy title to say: How to safely use Ivermectin to control mosquitos.
The plasma pharmacokinetic variables for patients were; maximum plasma concentration 52.0 ng ml-1; time to achieve maximum concentration, 5.2 h.; elimination half life, 35.0 h; and the area under the plasma concentration curve versus time, 2852 ng.h.ml-1. In healthy volunteers, the plasma ivermectin distribution was similar to that in patients, and both groups showed a tendency for a second rise in plasma concentration of the drug suggestive of enterohepatic recirculation. Ivermectin was detected in tissues obtained from patients. Fat showed the highest and most persistent levels, whilst values for skin, nodular tissues, and worms were comparable. Subcutaneous fascia contained the lowest concentrations.
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Added Sept. 29 2023:
Ivermectin plasma concentration
Ivermectin’s impact on mosquito mortality is directly related to the time there is a lethal concentration in the blood
The longer the drug remains in the blood, the more mosquitoes it will kill or disable. Any increase in duration of mosquitocidal concentrations is expected to contribute to additional mortality. Modelling shows that the time the drug remains in blood above mosquito-killing levels is the parameter that drives impact on transmission [50].
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Added Sept. 29 2023:
Use of ivermectin for the management of scabies in a nursing home
Abstract:
Ivermectin was used for the treatment of a scabies outbreak in a nursing home. Among the 128 residents, 42 presented pruritus or cutaneous lesions and scabies was parasitologically demonstrated in seven patients. All residents were treated with two 12 mg doses of ivermectin given two weeks apart. Ivermectin treatment associated with procedures for environmental disinfection led to the control of the outbreak. In only one case, was there a failure of the treatment. It is concluded that oral ivermectin is an effective and practical therapy for scabies in nursing homes.
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Added Sept. 29 2023:
A five-day course of ivermectin may reduce the duration of COVID-19 illness
The highest dose of ivermectin that we have used in our study is 12 mg (200 µg/kg) once daily for 5 consecutive days, which resulted in a significantly shorter time for viral clearance. Viral clearance was earlier in the 5-day ivermectin treatment arm when compared with the placebo group (9.7 days vs 12.7 days; p = 0.02), but this was not the case for the ivermectin + doxycycline arm (11.5 days; p = 0.27). Similarly, clinical trials with a 3-day, once-daily dose of 400 µg/kg oral ivermectin in dengue patients has been shown to be safe, with accelerated clearance of the dengue virus nonstructural protein 1
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Added Sept. 29 2023:
Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment
FDA-approved anti-parasite drug ivermectin is also an antibacterial, antiviral, and anticancer agent, which offers more potentiality to improve global public health, and it can effectively inhibit the replication of SARtarget="_blank"S-CoV-2 in vitro
The findings in this study demonstrate the broad-spectrum antiviral property of ivermectin benefiting for COVID-19 treatment in the context of predictive, preventive, and personalized medicine in virus-related diseases.
Viruses mentioned:
HCMV Mayo HPV Mayo EBV VWH HIV-1 NIH
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Added Sept. 29 2023:
“Doctor, I have a Sulfa Allergy”: Clarifying the Myths of Cross-Reactivity
Sulfonamide antibiotic reactions encompass the entire spectrum of 4 types of hypersensitivity reactions.
Type 1 hypersensitivity is IgE-mediated and may include an anaphylactic sequelae. (Interpretation: Anaphylactic shock is possible.)
Type 2 reactions involve antibody-mediated cytotoxic cellular injury that may result in various cytopenias. (Interpretation: A soldier of your immune system targets an undesirable cell, then attacks it, glues itself to the enemy cell, then destroys it. Cytopenia means the attack is now destroying even your red blood cells.)
Type 3 and type 4 hypersensitivity results in the formation of antigen–antibody immune complexes or a delayed T cell-mediated reaction, respectively, either of which may progress to the life-threatening Stevens-Johnson syndrome or toxic epidermal necrolysis. (Interpretation: Your immune system goes into tornado mode and starts destroying anything that it thinks could possibly be an enemy cell, even to the point of killing the host body.)
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Added Sept. 29 2023:
Ringworm-like skin lesion is not always tinea
Treatment with topical ivermectin 10 mg/g (1%) cream once daily resulted in an almost complete clinical resolution after 15 days [Figure - 4], but direct microscopy was still positive. Maintenance of the treatment for 2 months led to clinical and direct microscopic clearance at follow-up visit, with no relapses in the following 6 months.
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Mechanisms of ivermectin-induced wound healing
Ivermectin promotes wound healing partly through modulation of the inflammatory process and the levels of Transforming Growth Factor-Beta 1 and Vascular Endothelial Growth Factor. Low doses of ivermectin cream have the potential to be used in treating wounds with minimal scar tissue formation.
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IVERMECTIN ACTIVITY IN TREATMENT OF CATTLE DERMATOPYHTOSIS.
The aims of this study are to determine the prevalence of
cattle ringworm in native dairy farms of Diyala governorate, and the
distribution of T. verrucosum and treatment of the infection in the bovine by
ivermectin
Results: Statistical analysis reveals significantly less clearance time (50%) when ivermectin is used instead of topical antifungal 1% sulpher ointment in treating the disease. With less time of 13-24 days compared to 30-40 days. The treatment of ringworm disease in cattle with clearance rate of 100% is achieved using Ivermectin.
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Added Sept. 29 2023: Updated Oct. 02 2023
2021 Jan.: The broad spectrum host-directed agent ivermectin as an antiviral for SARS-CoV-2 ?
Ivermectin as a treatment for SARS-CoV-2 in humans has already been approved in a number of states and countries, including the Republic of Peru [44] and Northeastern Beni region of Bolivia [45]. Importantly, close to 70 trials worldwide are currently testing the clinical benefit of ivermectin to treat or prevent SARS-CoV-2 (see Table 3);
What does "host-directed" really mean? It means the therapy (in this case, Ivermectin) is directed at the host (you), in order to change the environment in which a virus in located. This makes the host an inhospitable place to live and inhibits its ability to replicate.
Starting in 2012, ivermectin’s antiviral properties have been progressively documented towards a number of RNA viruses, including human immunodeficiency virus (HIV)-1, influenza, flaviruses such as dengue and Zika, and most notably, SARS-CoV-2 (COVID-19)
4 ,
5 ,
7 ,
8 ,
9 ,
10 ,
11 ,
12 ,
13 ,
14 ,
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17 ,
as well as DNA viruses such as pseudorabies, polyoma and adenoviruses
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Added Sept. 29 2023:
2016: Ivermectin induces PAK1-mediated cytostatic autophagy in breast cancer
Avermectin is a potent broad-spectrum parasiticidal drug, the discovery of which led to the award of the 2015 Nobel Prize in physiology or medicine. Its derivative, ivermectin, has recently been reported to be a potential anticancer agent against colon cancer, ovarian cancer, melanoma, and leukemia. Our recent study demonstrates that ivermectin also exerts a promising anticancer effect for breast cancer as evidenced by marked growth inhibition after 24-h treatment with ivermectin in a range of breast cancer cell lines, with no obvious effects on nontumorigenic human breast cells. The anticancer activity of ivermectin was further confirmed in both mouse subcutaneous xenografts and orthotopic breast cancer models.
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Added Sept. 29 2023:
2006 Mar.: A case of crusted scabies with a bullous pemphigoid-like eruption and nail involvement
Case Study: Patient was diagnosed as having crusted scabies with bullous pemphigoid-like eruptions and nail involvement
prescribed oral ivermectin (two doses of 12 mg ivermectin with a 1-week interval) and topical lindane (1%gamma-BHC in petrolatum) for scabies with 5% salicylic acid in plastibase as an additional treatment for the crusted lesions on his soles. He showed remarkable improvement in 2 weeks, and his nails showed complete recovery after 7 weeks of occlusive dressing treatment with 1%gamma-BHC.
The bullous symptoms of this patient were considered to be due to the scabies, because the patient recovered completely after receiving treatment for scabies. Indirect immunofluorescent study is important to distinguish between scabies with blister formation and true bullous pemphigoid.
Top
Added Sept. 30 2023:
2012 Oct.: Human viruses: discovery and emergence
There are 219 virus species that are known to be able to infect humans.
The first of these to be discovered was yellow fever virus in 1901, and three to four new species are still being found every year.
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Added Oct. 23 2023:
2019 Feb. New indications for topical ivermectin 1% cream: a case series study
Topical ivermectin is an effective treatment for inflammatory papulopustular rosacea in adults. Positive therapeutic effects of ivermectin due to its potential anti-inflammatory properties could be achieved in the other facial dermatoses.
In December 2014, the US Food and Drug Administration approved 1% ivermectin cream for treatment of rosacea in adults while the first European approval was obtained in March 2015.
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Added Nov. 26 2023:
Published: 01 September 2022 Integrated analysis reveals FOXA1 and Ku70/Ku80 as targets of ivermectin in prostate cancer
Herein, we report the pharmacological effects and targets of ivermectin in prostate cancer.
Recently, several studies have explored the potential of ivermectin as a new cancer treatment [9 ,10 ,11 ]. In breast cancer, ivermectin decreases p21-activated kinase 1 (PAK1) expression by promoting its degradation and inducing cell autophagy [12 ]. In ovarian cancer, ivermectin can block the cell cycle and induce cell apoptosis through a Karyopherin-β1 (KPNB1) related mechanism [13 ]. In leukemia, ivermectin preferentially kills leukemia cells at low concentrations by increasing the influx of chloride ions into cells, which triggers plasma membrane hyperpolarization and reactive oxygen species (ROS) production [14 ].
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Added Mar. 24 2024:
FDA capitulates on some Ivermectin positions and comments
Retire FDA’s Consumer Update entitled, Why You Should Not Use
Ivermectin to Treat or Prevent COVID-19, originally posted on March 5,
2021, and revised on September 7, 2021 (ECF No. 12, Ex. 1), while
retaining the right to post a revised Consumer Update.
Delete and not republish
(1) FDA’s Twitter, LinkedIn, and Facebook posts from August 21, 2021 (ECF No. 12, Exs. 4, 5), that read, “You are not a horse. You are not a cow. Seriously, y’all. Stop it.”;
(2) FDA’s Instagram post from August 21, 2021 (ECF No. 12, Ex. 6), that reads, “You are not a horse. Stop it with the #ivermectin. It’s not authorized for treating #COVID.”
(3) FDA’s Twitter post from April 26, 2022 (ECF No. 12, Ex. 7), that reads, “Hold your horses, y’all. Ivermectin may be trending, but it still isn’t authorized or approved to treat COVID-19.”
(4) all other social media posts on FDA accounts that link to Why
You Should Not Use Ivermectin to Treat or Prevent COVID-19 (ECF No. 12,
Ex. 1) .