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Ivermectin

DISCLAIMER:THIS PAGE IS NOT INTENDED TO BE MEDICAL ADVICE!
It is infomation from various sources (as referenced), and may be formatted in a more understandable way.
The mention of any article, book, or document does not imply an endorsement of, or concurrence with those items.

Hovering over words, or phrases, that have a background color will display more information.

Table of Contents

Doseage Calculator

Do NOT use the information on this page as medical advise!
CAUTION! If you have alpha-gal syndrome, CONSIDER WELL, NOT TAKING THE IVERMECTIN MENTIONED ON THIS PAGE!
It could be very dangerous to your health!

The data on this page is gathered from various sources and presented here for your use.

Propylene Glycol in an ingredient in the both products mentioned on this page, so if there is a chance you might have AGS, you should consider NOT taking these products just to get the Ivermectin

Please use the Contact Me link if you find data that is incorrect.

Enter your weight in pounds in the yellow box. Then click (or tap) on the calculate button.

Dose Ratio mcg/kg Weight in lbs. Weight in kg Dose in mcg Dose in mg Dose in ml
200
400
800
1200

Caution - The dosage in pink is not recommended without the advice of a doctor!

There are predominantly two dosage ratios (200mcg/kg and 400mcg/kg) mentioned in many papers3, 18, 43. The 200 mcg/kg is a prophylactic (intended to prevent disease) and the 400 mcg/kg is an aggressive dose intended to treat a disease. Note: mcg is micrograms.

The aggressive dose may be administered orally once per day for 4 days. The first daily dose will put a percentage of the peak level of that dose into your system within a few minutes. The level in your system will then decline. At about 18 hours the level in your system will decline to 50% of the peak dose, and will continue to decline until you take the next dose.

When you take the next dose, the same effect happens, but this time the peak dose will be added to the residual that is left in your system from the previous dose(s). This same thing will happen after each dose.

The limit of the peaks will be reached after the 4th dose, which should be your last dose of the "agressive" dosage for the week.

Drug Half-Life Calculator

Following is a Half-Life Calculator where you can enter your calculated dose (from above). Enter the half-life of Ivermectin (18 hours). Enter how often you wish to take the dose (agressive = every 24 hours, prophylactic = 168 hours).

Global input

Dosage:ml (units don't matter)
You can Change this (default) dose and the graph will change dynamically.

Percentage elimination to consider (below) close enough to 100%:%
This percentage is explained in Science Direct half-life info.

Half-life:hours

If taken regularly

Time between doses:hours
Stabilized daily min–max (sum of residuals): –mg (–x)
To ramp up to maximum level (within the percentage above): doses ()
To ramp back down from maximum (within the percentage above): hours (days)

If taken once

Time for one isolated dose to drop within the percentage above: hours (days)
Level after 24 hours, for one isolated dose: mg

Sources of Ivermectin

I have stopped taking the Durvet product since I was diagnosed with alpha-gal.

I am now taking a compounded 20 mg dose daily.

I was prescribed the Ivermectin by my doctor and got the prescription filled by CareFirst Specialty Pharmacy.

Information About Ivermectin

  • Experiences with Ivermectin

    References:

    1. Top
      Added Sept. 29 2023:
      2006 Mar: A case of crusted scabies with a bullous pemphigoid-like eruption and nail involvement
      • Case Study: Patient was diagnosed as having crusted scabies with bullous pemphigoid-like eruptions and nail involvement.
      • prescribed oral ivermectin (two doses of 12 mg ivermectin with a 1-week interval) and topical lindane (1%gamma-BHC in petrolatum) for scabies with 5% salicylic acid in plastibase as an additional treatment for the crusted lesions on his soles. He showed remarkable improvement in 2 weeks, and his nails showed complete recovery after 7 weeks of occlusive dressing treatment with 1%gamma-BHC.
      • The bullous symptoms of this patient were considered to be due to the scabies, because the patient recovered completely after receiving treatment for scabies. Indirect immunofluorescent study is important to distinguish between scabies with blister formation and true bullous pemphigoid.
    2. Top
      Added Sep. 29, 2023
      CDC - Medications (search for Ivermectin)
      • About using Permethrin or Ivermectin for treading scabies
      • Remember, this is on the CDC.gov website.
      • Permethrin is safe and effective with a single application.
      • Multiple applications may be needed.
      • Can be applied to all the body from the neck down.
      • Wash off after 8 to 14 hours
      • Oral Ivermectin in not FDA approved for treating scabies
      • However, topical permethrin and oral ivermectin have similar efficacy for cure of scabies.
      • Stwo doses of oral ivermectin (200µg/kg/dose) should be taken with food, each 7 to 14 days apart.
      • And more...
    3. Top
      Added Sept. 29 2023: Updated Oct. 2 2023
      A five-day course of ivermectin for the treatment of COVID-19 may reduce the duration of illness
      • The most successful arm of this trial administered oral ivermectin alone (12 mg once daily for 5 days). 12mg equates to 1.2ml. This treatment was effective in clearing the virus in 9.7 days vs 12.7 days of the next most effective treatment.
      • The results of this trial begs the questions: What would be the results of doubling the dose? What would be the results of elongating the dose?
      • The ivermectin is affordable and ranges from US$ 0.60 to US$ 1.80 for 5-day treatment.
      • Same article posted at International Journal of Infectious Disease.
    4. Top
      Added Sept. 29 2023:
      Anti-parasite drug ivermectin can suppress ovarian cancer by regulating lncRNA-EIF4A3-mRNA axes
      • Recently, ivermectin, as a promising anticancer agent, showed remarkable ability to block tumor progression
    5. Top
      Added Sept. 29 2023:
      Ivermectin-induced drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome
      • Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome, also known as drug-induced hypersensitivity syndrome, is a rare, potentially life-threatening adverse drug reaction with an estimated mortality rate up to 10%.
      • These adverse reactions occur within 7 days of the administration of ivermectin and are likely related to the intensity of the filarial (parasite) infection and the release of parasite antigen. Since the eosinophil storm is likely caused by the dying parasites causing an avalanch of lymphosites, is this where control points should be established?
      • Might the Mazzotti effect also be triggered by large populations of bacteri and viruses?
    6. Top
      Added Sept. 29 2023:
    7. Top
      Added Sept. 29 2023:
      The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro
      • Ivermectin shows that it decreases a given Covid viral colony by 5000 fold withing 48 hours after application.
    8. Top
      Added Sept. 29 2023:
      2021 Use of Ivermectin Is Associated With Lower Mortality in Hospitalized Patients With Coronavirus Disease 2019

      We showed that ivermectin administration was associated significantly with lower mortality among patients with COVID-19, particularly in patients with more severe pulmonary involvement.

    9. Top
      Added Sept. 29 2023:
      2018 Safety and pharmacokinetic profile of fixed-dose ivermectin with an innovative 18mg tablet in healthy adult volunteers

      This study was conducted in healthy adult volunteers in which we compared 3 treatment regimens: the weight-based reference standard versus 2 experimental regimens of fix-dose 18 and 36 mg using 18 mg tablets. All 54 volunteers received the 3 treatments sequentially. The results confirmed that the fixed-dose regimen (both 18 mg and 36 mg) are as safe as the standard dosage and could justify the use of fix dosing regimens rather than the current weight based strategy.

    10. Top
      Added Sept. 29 2023:
      2008 The Pharmacokinetics and Interactions of Ivermectin in Humans—A Mini-review

      A brief review of the information availabile regarding the pharmacokinetics and interactions of ivermectin in humans.

    11. Top
      Added Sept. 29 2023:
      2012 Ivermectin Inhibits Growth of Chlamydia trachomatis in Epithelial Cells

      Here we show that ivermectin also inhibits infection of epithelial cells by the bacterial pathogen, Chlamydia trachomatis, at doses that could be envisioned clinically for sexually-transmitted or ocular infections by Chlamydia.

      For use in humans as an anti-helminthic, ivermectin is typically received orally at a dose of 150 µg/kg body weight, and peak plasma concentrations from such dosage reach around 60 nM

    12. Top
      Added Sept. 29 2023:
      1996 Ivermectin distribution in the plasma and tissues of patients infected with Onchocerca volvulus

      The plasma levels for patients, after 5.2 hours, peaked at 52.0 ng/ml. The elimination half life was 35.0 h;Note: This does not match the accepted HL of 18 hours and the area under the plasma concentration curve versus time, 2852 ng.h.ml-1. In healthy volunteers, the plasma ivermectin distribution was similar to that in patients, and both groups showed a tendency for a second rise in plasma concentration of the drug suggestive of enterohepatic recirculation. Ivermectin was detected in tissues obtained from patients. Fat showed the highest and most persistent levels, whilst values for skin, nodular tissues, and worms were comparable. Subcutaneous fascia contained the lowest concentrations.

    13. Top
      Added Sept. 29 2023:
      2023 Pharmacokinetics of ivermectin metabolites and their activity against Anopheles stephensi mosquitoes

      Survival of malaria transmitting Anopheles mosquitoes is strongly decreased after feeding on humans recently treated with ivermectin. Currently, mass drug administration of ivermectin is under investigation as a potential novel malaria vector control tool to reduce Plasmodium transmission by mosquitoes. A "post-ivermectin effect" has also been reported, in which the survival of mosquitoes remains reduced even after ivermectin is no longer detectable in blood meals.

    14. Top
      Added Sept. 29 2023:
      2017 Ivermectin to reduce malaria transmission I. Pharmacokinetic and pharmacodynamic considerations regarding efficacy and safety
      • A fancy title to say: How to safely use Ivermectin to control mosquitos.
      • In humans, studies with radio-labelled ivermectin show that peak plasma concentration of metabolites is about twice that of the parent drug and occurs later, at 7 h (vs four for parent drug). Plasma metabolites are less polar than the parent drug and could be fatty acid ester conjugates of the monosaccharides or aglycone of the parent drug.
      • The plasma half-life of metabolites is about 72 h, fourfold that of the parent drug.
    15. Top
      Added Sept. 29 2023:
      Ivermectin plasma concentration

      Ivermectin’s impact on mosquito mortality is directly related to the time there is a lethal concentration in the blood

      The longer the drug remains in the blood, the more mosquitoes it will kill or disable. Any increase in duration of mosquitocidal concentrations is expected to contribute to additional mortality. Modelling shows that the time the drug remains in blood above mosquito-killing levels is the parameter that drives impact on transmission [50].

    16. Top
      Added Sept. 29 2023:
    17. Top
      Added Sept. 29 2023:
      Ivermectin plasma concentration

      The next curves indicate change in max plasma concentrattion depending on dose, how multiple doses affect efficacy.

    18. Top
      Added Sept. 29 2023:
      2023 Ivermectin systemic availability in adult volunteers treated with different oral pharmaceutical formulations

      This is an Argentinian study published in Biomedicine & Pharmacotherapy Volume 160, April 2023, 114391.

    19. Top
      Added Sept. 29 2023:
      Efficacy and Safety of Single and Double Doses of Ivermectin versus 7-Day High Dose Albendazole for Chronic Strongyloidiasis

      This is an Argentinian study published in Biomedicine & Pharmacotherapy Volume 160, April 2023, 114391.

    20. Top
      Added Sept. 29 2023:
      Use of ivermectin for the management of scabies in a nursing home

      Abstract: Ivermectin was used for the treatment of a scabies outbreak in a nursing home. Among the 128 residents, 42 presented pruritus or cutaneous lesions and scabies was parasitologically demonstrated in seven patients. All residents were treated with two 12 mg doses of ivermectin given two weeks apart. Ivermectin treatment associated with procedures for environmental disinfection led to the control of the outbreak. In only one case, was there a failure of the treatment. It is concluded that oral ivermectin is an effective and practical therapy for scabies in nursing homes.

    21. Top
      Added Sept. 29 2023:
      A five-day course of ivermectin may reduce the duration of COVID-19 illness
      • The highest dose of ivermectin that we have used in our study is 12 mg (200 µg/kg) once daily for 5 consecutive daysNote: This dose is calculated for a 133 pound person., which resulted in a significantly shorter time for viral clearance. Viral clearance was earlier in the 5-day ivermectin treatment arm when compared with the placebo group (9.7 days vs 12.7 days; p = 0.02), but this was not the case for the ivermectin + doxycycline arm (11.5 days; p = 0.27). Similarly, clinical trials with a 3-day, once-daily dose of 400 µg/kg oral ivermectin in dengue patients has been shown to be safe, with accelerated clearance of the dengue virus nonstructural protein 1
    22. Top
      Added Sept. 29 2023:
      Combined therapy with ivermectin and doxycycline can effectively alleviate the cytokine storm of COVID-19 infection amid vaccination drive: A narrative review

      After analyzing the results of the different clinical trials it is concluded that the use of ivermectin in combination with doxycycline can prove to be an effective, safe and affordable therapeutic regimen for relieving the cytokine storm of COVID-19 infection.

    23. Top
      Added Sept. 29 2023:
      Role of ivermectin in the prevention of SARS-CoV-2 infection among healthcare workers in India: A matched case-control study

      Two-dose ivermectin prophylaxis at a dose of 300 µg/kg with a gap of 72 hours was associated with a 73% reduction of SARS-CoV-2 infection among healthcare workers for the following month. Chemoprophylaxis has relevance in the containment of pandemic.

    24. Top
      Added Sept. 29 2023:
      Antiviral Effect of High-Dose Ivermectin in Adults with COVID-19: A Pilot Randomised, Controlled, Open Label, Multicentre Trial

      A concentration dependent antiviral activity of oral high dose IVM was identified in this pilot trial at a dosing regimen that was well tolerated.

      Interpretation: When 600 mcg/kg IVM was administered, antiviral effects were observed, and that dose was well tolerated.

    25. Top
      Added Sept. 29 2023:
    26. Top
      Added Sept. 29 2023:
      Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment

      FDA-approved anti-parasite drug ivermectin is also an antibacterial, antiviral, and anticancer agent, which offers more potentiality to improve global public health, and it can effectively inhibit the replication of SARtarget="_blank"S-CoV-2 in vitro

      The findings in this study demonstrate the broad-spectrum antiviral property of ivermectin benefiting for COVID-19 treatment in the context of predictive, preventive, and personalized medicine in virus-related diseases.

      Viruses mentioned: HCMVMayo, HPVMayo, EBVVWH, and HIV-1NIH

    27. Top
      Added Sept. 29 2023:
      The broad spectrum antiviral ivermectin targets the host nuclear transport importin a/ß1 heterodimer

      Finally, we show for the first time that ivermectin can limit infection by the DENV-related West Nile virus at low (µM)

    28. Top
      Added Sept. 29 2023:
      Efficacy and Safety of High-Dose Ivermectin for Reducing Malaria Transmission (IVERMAL): Protocol for a Double-Blind, Randomized, Placebo-Controlled, Dose-Finding Trial in Western Kenya

      A concentration dependent antiviral activity of oral high dose IVM was identified in this pilot trial at a dosing regimen that was well tolerated.

      Interpretation: When 600 mcg/kg IVM was administered, antiviral effects were observed, and that dose was well tolerated.

    29. Top
      Added Sept. 29 2023:
      Clorsulon pharmacokinetics in sheep and goats following oral and intravenous administration

      There is a relative dirth of studies regarding Clorsulon: A site:nih.gov search shows 905 vs 35,800 for ivermectin.

      This is a sheep & goat study that speaks to some questions regarding Clorsulon.: After a single dose of 7 mcg/kg, peak plasma consentration @ 14h (goats) 15h (sheep). There's more in the abstract.

    30. Top
      Added Sept. 29 2023:
    31. Top
      Added Sept. 29 2023:
      A scabies outbreak in a diabetic and collagen disease ward: Management and prevention

      It was considered that the absence of burrows, eggs and mites did not eliminate the risk of scabies infestation. Ivermectin (Maruho Co., Ltd., Osaka, Japan) was administered orally as therapeutic administration (200µg/kg twice at two-week intervals) in 6 patients and as a preventive (one dose of 200µg/kg) in 35 individuals.

    32. Top
      Added Sept. 29 2023:
      “Doctor, I have a Sulfa Allergy”: Clarifying the Myths of Cross-Reactivity

      Sulfonamide antibiotic reactions encompass the entire spectrum of 4 types of hypersensitivity reactions.

      • Type 1 hypersensitivity is IgE-mediated and may include an anaphylactic sequelae. (Interpretation: Anaphylactic shock is possible.)
      • Type 2 reactions involve antibody-mediated cytotoxic cellular injury that may result in various cytopenias. (Interpretation: A soldier of your immune system targets an undesirable cell, then attacks it, glues itself to the enemy cell, then destroys it. Cytopenia means the attack is now destroying even your red blood cells.)
      • Type 3 and type 4 hypersensitivity results in the formation of antigen–antibody immune complexes or a delayed T cell-mediated reaction, respectively, either of which may progress to the life-threatening Stevens-Johnson syndrome or toxic epidermal necrolysis. (Interpretation: Your immune system goes into tornado mode and starts destroying anything that it thinks could possibly be an enemy cell, even to the point of killing the host body.)
    33. Top
      Added Sept. 29 2023:
      Ivermectin-Clorsulon Overdose in Attempting Coronavirus Disease 2019 Prophylaxis: A Case Report

      I believe the conclusion of this study should be challenged. Is it more likely this woman suffered an anaphlyactic response to the Clorsulon, possibly exacerbated by an eosinophil storm, described as a DRESS event?

      Because Clorsulon is a sulfonamide, is it possible a hypersensitivity reaction was triggered?

    34. Top
      Added Sept. 29 2023:
      Ivermectin for COVID-19: Addressing Potential Bias and Medical Fraud

      This is a re-submission of the original paper that was challenged and then withdrawn. The retraction notice is available here.

      The original is available here.

    35. Top
      Added Sept. 29 2023:
      Ringworm-like skin lesion is not always tinea

      Treatment with topical ivermectin 10 mg/g (1%) cream once daily resulted in an almost complete clinical resolution after 15 days [Figure - 4], but direct microscopy was still positive. Maintenance of the treatment for 2 months led to clinical and direct microscopic clearance at follow-up visit, with no relapses in the following 6 months.

    36. Top
      Added Sept. 29 2023:
      Mechanisms of ivermectin-induced wound healing

      Ivermectin promotes wound healing partly through modulation of the inflammatory process and the levels of Transforming Growth Factor-Beta 1 and Vascular Endothelial Growth Factor. Low doses of ivermectin cream have the potential to be used in treating wounds with minimal scar tissue formation.

    37. Top
      Added Sept. 29 2023:
      IVERMECTIN ACTIVITY IN TREATMENT OF CATTLE DERMATOPYHTOSIS.

      The aims of this study are to determine the prevalence of cattle ringworm in native dairy farms of Diyala governorate, and the distribution of T. verrucosum and treatment of the infection in the bovine by ivermectin

      Results: Statistical analysis reveals significantly less clearance time (50%) when ivermectin is used instead of topical antifungal 1% sulpher ointment in treating the disease. With less time of 13-24 days compared to 30-40 days. The treatment of ringworm disease in cattle with clearance rate of 100% is achieved using Ivermectin.

    38. Top
      Added Sept. 29 2023:
      Inhibition of Human Adenovirus Replication by the Importin a/ß1 Nuclear Import Inhibitor Ivermectin

      Our results demonstrate that ivermectin, an FDA-approved antiparasitic agent, is effective at inhibiting replication of several HAdV types in vitro.

    39. Top
      Added Sept. 29 2023:
      A systematic review of experimental evidence for antiviral effects of ivermectin and an in silico analysis of ivermectin's possible mode of action against SARS-CoV-2

      Ivermectin is a putative (generally accepted as) antiviral compound.

      My question: If that is true why doesn't the medical industry act like it?

    40. Top
      Added Sept. 29 2023:
    41. Top
      Added Sept. 29 2023:
      William C. Campbell, Satoshi Omura awarded Nobel prize for their discoveries concerning a novel therapy (Avermectin and Ivermectin) against infections caused by roundworm parasites and Tu Youyou for her discoveries concerning a novel therapy (Ivermectin) against Malaria

      Ivermectin as a treatment for SARS-CoV-2 in humans has already been approved in a number of states and countries, including the Republic of Peru [44] and Northeastern Beni region of Bolivia [45]. Importantly, close to 70 trials worldwide are currently testing the clinical benefit of ivermectin to treat or prevent SARS-CoV-2 (see Table 3);

    42. Top
      Added Sept. 29 2023: Updated Oct. 02 2023
      2021 Jan.: The broad spectrum host-directed agent ivermectin as an antiviral for SARS-CoV-2 ?

      Ivermectin as a treatment for SARS-CoV-2 in humans has already been approved in a number of states and countries, including the Republic of Peru [44] and Northeastern Beni region of Bolivia [45]. Importantly, close to 70 trials worldwide are currently testing the clinical benefit of ivermectin to treat or prevent SARS-CoV-2 (see Table 3);

      What does "host-directed" really mean? It means the therapy (in this case, Ivermectin) is directed at the host (you), in order to change the environment in which a virus in located. This makes the host an inhospitable place to live and inhibits its ability to replicate.

      Starting in 2012, ivermectin’s antiviral properties have been progressively documented towards a number of RNA viruses, including human immunodeficiency virus (HIV)-1, influenza, flaviruses such as dengue and Zika, and most notably, SARS-CoV-2 (COVID-19) 4, 5, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, as well as DNA viruses such as pseudorabies, polyoma and adenoviruses 18, 19, 20,

    43. Top
      Added Sept. 29 2023:
      2016: Ivermectin induces PAK1-mediated cytostatic autophagy in breast cancer

      Avermectin is a potent broad-spectrum parasiticidal drug, the discovery of which led to the award of the 2015 Nobel Prize in physiology or medicine. Its derivative, ivermectin, has recently been reported to be a potential anticancer agent against colon cancer, ovarian cancer, melanoma, and leukemia. Our recent study demonstrates that ivermectin also exerts a promising anticancer effect for breast cancer as evidenced by marked growth inhibition after 24-h treatment with ivermectin in a range of breast cancer cell lines, with no obvious effects on nontumorigenic human breast cells. The anticancer activity of ivermectin was further confirmed in both mouse subcutaneous xenografts and orthotopic breast cancer models.

    44. Top
      Added Sept. 29 2023:
      PDF: IVERMECTIN - ivermectin tablet Edenbridge Pharmaceuticals LLC.

      Edenbridge detailed specification and usage sheet for Ivermectin.

    45. Top
      Added Sept. 29 2023:
      2006 Mar.: A case of crusted scabies with a bullous pemphigoid-like eruption and nail involvement

      Case Study: Patient was diagnosed as having crusted scabies with bullous pemphigoid-like eruptions and nail involvement

      prescribed oral ivermectin (two doses of 12 mg ivermectin with a 1-week interval) and topical lindane (1%gamma-BHC in petrolatum) for scabies with 5% salicylic acid in plastibase as an additional treatment for the crusted lesions on his soles. He showed remarkable improvement in 2 weeks, and his nails showed complete recovery after 7 weeks of occlusive dressing treatment with 1%gamma-BHC.

      The bullous symptoms of this patient were considered to be due to the scabies, because the patient recovered completely after receiving treatment for scabies. Indirect immunofluorescent study is important to distinguish between scabies with blister formation and true bullous pemphigoid.

    46. Top
      Added Sept. 29 2023:
      2023 Feb.: Effect of Higher-Dose Ivermectin for 6 Days vs Placebo on Time to Sustained Recovery in Outpatients With COVID-19A Randomized Clinical Trial

      Question: Does ivermectin, with a maximum targeted dose of 600 µg/kg daily for 6 days, compared with placebo, shorten symptom duration among adult (=30 years) outpatients with symptomatic mild to moderate COVID-19?

      Conclusions and Relevance: Among outpatients with mild to moderate COVID-19, treatment with ivermectin, with a maximum targeted dose of 600 µg/kg daily for 6 days, compared with placebo did not improve time to sustained recovery. These findings do not support the use of ivermectin in patients with mild to moderate COVID-19.

    47. Top
      Added Sept. 30 2023:
      2022 Sep.: Integrated analysis reveals FOXA1 and Ku70/Ku80 as targets of ivermectin in prostate cancer

      Our findings demonstrate the anticancer effect of ivermectin in prostate cancer, indicating that its use may be a new therapeutic approach for prostate cancer.

    48. Top
      Added Sept. 30 2023:
      2012 Oct.: Human viruses: discovery and emergence

      There are 219 virus species that are known to be able to infect humans.

      The first of these to be discovered was yellow fever virus in 1901, and three to four new species are still being found every year.

    49. Top
      Added Oct. 1 2023:
      2012 May.: Ivermectin treatment for massive orbital myiasis in an empty socket with concomitant scalp pediculosis

      Report of a rare case of massive orbital myiasis (fly maggots) following recent lid injury, occurring in the empty socket of an elderly lady, who had concurrent scalp pediculosis (lice). The orbital myiasis was effectively treated with the broad-spectrum antiparasitic agent, ivermectin, thus precluding the need for an exploratory surgery. Ivermectin was also effective in managing the concurrent scalp pediculosis.

    50. Top
      Added Oct. 1 2023:
      1998 Oct.: Treatment of Pediculus humanus var. capitis infestation in Cowlitz County, Washington, with ivermectin and the LiceMeister comb

      A single oral dose of ivermectin was generally effective for the treatment of head lice, especially when used in combination with a LiceMeister® comb and when the whole family was treated. About 15% of patients required a second dose 24 h after the first.

    51. Top
      Added Oct. 5 2023:
      2023 Oct. Evaluation of therapeutic potential of ivermectin against complete Freund's adjuvant-induced arthritis in rats: Involvement of inflammatory mediators

      Ivermectin has significant antiarthritic properties and can be a novel treatment agent for the management of rheumatoid arthritis patients suffering from strongyloidiasis.

      The conclusion of this study begs the question: Why for strongyloidiasis patients and not others?

    52. Top
      Added Oct. 7 2023:
      2009 Mar. The pharmacokinetics of orally administered ivermectin in African elephants (Loxodonta africana): implications for parasite elimination

      Unique method of measuring plasma levels of Ivermectin. Describing the dosing usefully i.e. mg/kg and describing the plasma and fecal concentrations usefully i.e. ng/ml.

      The study was conducted in a manner which eliminates many biological variables.

    53. Top
      Added Oct. 23 2023:
      2019 Feb. New indications for topical ivermectin 1% cream: a case series study

      Topical ivermectin is an effective treatment for inflammatory papulopustular rosacea in adults. Positive therapeutic effects of ivermectin due to its potential anti-inflammatory properties could be achieved in the other facial dermatoses.

      In December 2014, the US Food and Drug Administration approved 1% ivermectin cream for treatment of rosacea in adults while the first European approval was obtained in March 2015.

    54. Top
      Added Oct. 23 2023:
      2019 FDA list of Ivermectin products approved for human use.
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      Added Nov. 26 2023:
      Published: 01 September 2022 Integrated analysis reveals FOXA1 and Ku70/Ku80 as targets of ivermectin in prostate cancer

      Herein, we report the pharmacological effects and targets of ivermectin in prostate cancer.

      Recently, several studies have explored the potential of ivermectin as a new cancer treatment [9,10,11]. In breast cancer, ivermectin decreases p21-activated kinase 1 (PAK1) expression by promoting its degradation and inducing cell autophagy [12]. In ovarian cancer, ivermectin can block the cell cycle and induce cell apoptosis through a Karyopherin-β1 (KPNB1) related mechanism [13]. In leukemia, ivermectin preferentially kills leukemia cells at low concentrations by increasing the influx of chloride ions into cells, which triggers plasma membrane hyperpolarization and reactive oxygen species (ROS) production [14].

    56. Top
      Added Jan. 4 2024:
      2024 Jan 1. Impact of comorbidities and inflammatory markers on mortality of COVID-19 patients

      The study showed that higher neutrophil levels were linked to mortality in tocilizumab-treated patients, while ivermectin showed promise in increasing survival rates.

    57. Top
      Added Jan. 16 2024:
      Is Glycerin Vegan? What To Know

      Section "Is Glycerin Vegan" speaks to glycerol possibly being animal based.

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      Added Jan. 26 2024:
      Ivermectin ameliorates bleomycin-induced lung fibrosis in male rats by inhibiting the inflammation and oxidative stress
      • This study indicate that ivermectin may have therapeutic benefits for IPF, likely due to its ability to reduce inflammation and mitigate oxidative stress-induced toxicity.
    59. Top
      Added Mar. 24 2024:
      Eprinomectin: a derivative of ivermectin suppresses growth and metastatic phenotypes of prostate cancer cells by targeting the β-catenin signaling pathway

      Study shows that EP has tremendous potential to target metastatic PCa cells and provides new avenues for therapeutic approaches for advanced PCa.

    60. Top
      Added Mar. 24 2024:
      FDA capitulates on some Ivermectin positions and comments

      Retire FDA’s Consumer Update entitled, Why You Should Not Use Ivermectin to Treat or Prevent COVID-19, originally posted on March 5, 2021, and revised on September 7, 2021 (ECF No. 12, Ex. 1), while retaining the right to post a revised Consumer Update.

      Delete and not republish

      • (1) FDA’s Twitter, LinkedIn, and Facebook posts from August 21, 2021 (ECF No. 12, Exs. 4, 5), that read, “You are not a horse. You are not a cow. Seriously, y’all. Stop it.”;
      • (2) FDA’s Instagram post from August 21, 2021 (ECF No. 12, Ex. 6), that reads, “You are not a horse. Stop it with the #ivermectin. It’s not authorized for treating #COVID.”
      • (3) FDA’s Twitter post from April 26, 2022 (ECF No. 12, Ex. 7), that reads, “Hold your horses, y’all. Ivermectin may be trending, but it still isn’t authorized or approved to treat COVID-19.”
      • (4) all other social media posts on FDA accounts that link to Why You Should Not Use Ivermectin to Treat or Prevent COVID-19 (ECF No. 12, Ex. 1).
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      Added Mar. 24 2024:
      Ivermectin, a potential anticancer drug derived from an antiparasitic drug
      • IVM not only has strong effects on parasites but also has potential antiviral effects. IVM can inhibit the replication of flavivirusCDC-1 by targeting the NS3 helicase
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      Added Mar. 29 2024:
      The Benefit of a Single Oral Dose of Ivermectin in Humans: The Adverse Effects on Cimex lectularius L. Populations and Fecundity
      • Objective: To measure the population size and fecundity (ability to reproduce) of the common bed bug after feeding it with the blood obtained from human subjects who have consumed a single dose of ivermectin.
      • Conclusions: There were significant reductions in bed bug population size and fecundity in insects that fed on blood obtained from human study subjects up to 96 hours after they have consumed a single oral dose of ivermectin.
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      Added Jul. 16 2024:
      2024 June: Mosquitocidal effect of ivermectin-treated nettings and sprayed walls on Anopheles gambiae s.s.
      • Ivermectin (IVM) has been proposed as a new tool for malaria control as it is toxic on vectors feeding on treated humans or cattle.
      • IVM may have a direct mosquitocidal effect when applied on bed nets or sprayed walls.
      • The potential for IVM application as a new insecticide for long-lasting insecticidal nets (LLINs) and indoor residual spraying (IRS) was tested in this proof-of-concept study in a laboratory and semi-field environment.
      • The results showed a direct mosquitocidal effect of IVM on this mosquito strain as all mosquitoes died by 24 h after exposure to IVM.
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      Added Aug. 20 2024:
      2011 Feb: Ivermectin, ‘Wonder drug’ from Japan: the human use perspective
      • Ivermectin is also highly effective against the ixodid tick Rhipicephalus (Boophilus) microplus, a cattle parasites in the tropics and subtropics.
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      Added Oct. 5 2024:
      2022 Dec: Effect of Ivermectin prophylaxis in prevention of COVID 19: Meta-analysis and systematic review
      • Usual safe medication doses of Ivermectin drug in human beings is 0.2–0.4 mg/kg.
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      Added Oct. 13 2024:
      Nov. 2023 IVERMECTIN - ivermectin tablet Edenbridge Pharmaceuticals LLC.
      • Subjects received oral doses of 30 to 120 mg (333 to 2000 mcg/kg) ivermectin in a fasted state or 30 mg (333 to 600 mcg/kg) ivermectin following a standard high-fat (48.6 g of fat) meal
      • Administration of 30 mg ivermectin following a high-fat meal resulted in an approximate 2.5-fold increase in bioavailability relative to administration of 30 mg ivermectin in the fasted state.
      • Significant lethality was observed in mice and rats after single oral doses of 25 to 50 mg/kg and 40 to 50 mg/kg, respectively. No significant lethality was observed in dogs after single oral doses of up to 10 mg/kgNote: These are more than 100 times the recommended dose.
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      Added Oct. 17 2024:
      Jan. 2014 Human Demodex Mite: The Versatile Mite of Dermatological Importance
      • After clinical manifestations (of demodex mites), the mites may be temporarily eradicated with topical insecticides, especially crotamiton cream, permethrin cream, and also with topical or systemic metronidazole. In severe cases, such as those with HIV infection, oral ivermectin may be recommended.
      • Colonization of the skin with Demodex could be a reflection of immune response of the host to organism.