DISCLAIMER:THIS PAGE IS NOT INTENDED TO BE MEDICAL ADVICE!
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Doseage Calculator
Do NOT use the information on this page as medical advise!
The data on this page is gathered from various sources and presented here for your use.
Propylene Glycol in an ingredient in the both products mentioned on this page, so if there is a chance you might have AGS, you should consider NOT taking these products just to get the Ivermectin
Please contact me if you find data that is incorrect.
Enter your weight in pounds in the yellow box. Then click (or tap) on the calculate button.Return
Caution - The dosage in pink is not recommended without the advice of a doctor!
There are predominantly two dosage ratios (200mcg/kg and 400mcg/kg) mentioned in many papers3, 18, 43
The aggressive dose may be administered orally once per day for 4 days. The first daily dose will put a percentage of the peak level of that dose into your system within a few minutes. The level in your system will then decline. At about 18 hours the level in your system will decline to 50% of the peak dose, and will continue to decline until you take the next dose.
When you take the next dose, the same effect happens, but this time the peak dose will be added to the residual that is left in your system from the previous dose(s). This same thing will happen after each dose.
The limit of the peaks will be reached after the 4th dose, which should be your last dose of the "agressive" dosage for the week.
Drug Half-Life CalculatorReturn
Following is a Half-Life Calculator where you can enter your calculated dose (from above). Enter the half-life of Ivermectin (18 hours). Enter how often you wish to take the dose (agressive = every 24 hours, prophylactic = 168 hours).
Global input
Half-life:
If taken regularly
Time between doses:
Stabilized daily min–max (sum of residuals):
To ramp up to maximum level (within the percentage above):
Ramp up details
To ramp back down from maximum (within the percentage above):
If taken once
Time for one isolated dose to drop within the percentage above:
Level after 24 hours, for one isolated dose:
Sources of Ivermectin Return I have stopped taking the Durvet product since I was diagnosed with alpha-gal.
I am now taking a compounded 20 mg dose daily.
I was prescribed the Ivermectin by my doctor and got the prescription filled by CareFirst Specialty Pharmacy .
DurvetImage The brand I was using
Sold at Tractor Supply
I purchased the 250ml bottle for $79.99 and expect it to last at least a year.
That puts my cost at $0.32 USD per ml. or $0.64 USD per dose for my weight.
Noromectrin (Green Label)I do NOT recommended this product for human consumption!
I believe the Clorsulon in this product represents a significant danger to those who have any sensitivity to sulfonamide drugs.
I am still researching this product. I will update as I gather information.
This product is sold at my local MFA
Sourced from India company
Ivermectin Tablet - Uses, Side Effects, Composition & Price This is a website in India with info that can be used to comparison shop.
Shop around and you can find IVM (Ivermectin) as low as $.02 USD per 12mg tablet.
Update: Contacted supplier in India and the cost for 1 box (200 12mg tablets) with shipping and customs would be $89.00 USD. That's more than my per dose cost.
Information About IvermectinReturn
CDC says it should be used for scabies and worms.1
May shorten duration of Covid-19.2 , 6
May participate in the war against cancers (prostate, breast, ovarian, leukemia)3, 55 In vitro and in vivo antitumor activities of ivermectin.4
Ivermectin-induced drug reaction5, 6
Associated with lower Covid-19 mortality.7
A new tool to eliminate malaria?27 A possible weapon against West Nile Virus?26
Nobel prizes awarded for discovery and practical use of Ivermectin. 12, 40
South Carolina Dept. of Health tries to bury the truth of Ivermectin. 39
2023 study finds IVM not effective as COVID treatment45
2019 FDA approved 1% Ivermectin for treatment of rosacea in adults.53, 54,
2024 Ivermectin shows promise of improved Covid survival rates.56
2024 Ivermectin may have therapeutic benefits for IPF.58
2023 Eprinomectin: a derivative of ivermectin suppresses growth and metastatic phenotypes of prostate cancer cells59
2023 FDA capitulates on some Ivermectin positions and comments60
2021 Ivermectin is known to inhibit the replication of flavivirus.61
2019 Significant reduction in bed bug population after insects feed on blood of person that has taken only 1 dose of Ivermectin.62
2024 Mosquitocidal effect of ivermectin-treated nettings and sprayed walls on Anopheles gambiae s.s.63
2011 Ivermectin, ‘Wonder drug’ from Japan: the human use perspective.64
2022 Usual safe medication doses of Ivermectin drug in human beings is 0.2–0.4 mg/kg.65
2014 Severe clinical manifestation of demodex mites may require Ivermectin.67
Experiences with Ivermectin
Personal
After the first dose, I experienced slight symptoms of vertigo and a short period (about an hour) of very slightly blurred vision (not anywhere near like removing my glasses).
Dose 2, 3 and 4 on days 2, 3 and 4, each precipitated similar vertigo symptoms, although with shorter and less intense symptoms each successive day.
My 5th dose was taken 168 hours (1 week) after number 4 dose and there were no side effects experienced.
Dose #6 was taken 168 hours after dose #5. No side effects noted.
Case studies
Report of DRESS symptoms5
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Added Sept. 29 2023:
2006 Mar: A case of crusted scabies with a bullous pemphigoid-like eruption and nail involvement
Case Study: Patient was diagnosed as having crusted scabies with bullous pemphigoid-like eruptions and nail involvement.
prescribed oral ivermectin (two doses of 12 mg ivermectin with a 1-week interval) and topical lindane (1%gamma-BHC in petrolatum) for scabies with 5% salicylic acid in plastibase as an additional treatment for the crusted lesions on his soles. He showed remarkable improvement in 2 weeks, and his nails showed complete recovery after 7 weeks of occlusive dressing treatment with 1%gamma-BHC.
The bullous symptoms of this patient were considered to be due to the scabies, because the patient recovered completely after receiving treatment for scabies. Indirect immunofluorescent study is important to distinguish between scabies with blister formation and true bullous pemphigoid.
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Added Sep. 29, 2023
CDC - Medications (search for Ivermectin)
About using Permethrin or Ivermectin for treading scabies
Remember, this is on the CDC.gov website.
Permethrin is safe and effective with a single application.
Multiple applications may be needed.
Can be applied to all the body from the neck down.
Wash off after 8 to 14 hours
Oral Ivermectin in not FDA approved for treating scabies
However, topical permethrin and oral ivermectin have similar efficacy for cure of scabies.
Stwo doses of oral ivermectin (200µg/kg/dose) should be taken with food, each 7 to 14 days apart.
And more...
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Added Sept. 29 2023: Updated Oct. 2 2023
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Added Sept. 29 2023:
Ivermectin-induced drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome
Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome, also known as drug-induced hypersensitivity syndrome, is a rare, potentially life-threatening adverse drug reaction with an estimated mortality rate up to 10%.
These adverse reactions occur within 7 days of the administration of ivermectin and are likely related to the intensity of the filarial (parasite) infection and the release of parasite antigen. Since the eosinophilEosinophils are one of several white blood cells that support your immune system. They're part of your body's defense system against allergens and help protect your body from fungal and parasitic infections. Certain medical conditions and medications can cause high eosinophil counts. storm is likely caused by the dying parasites causing an avalanch of lymphosites, is this where control points should be established?
Might the Mazzotti effect also be triggered by large populations of bacteri and viruses?
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Added Sept. 29 2023:
The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro
Ivermectin shows that it decreases a given Covid viral colony by 5000 fold withing 48 hours after application.
My Comment Added Dec. 16 2024:
To express a 5000-fold reduction in viral RNA:
In Log Nomenclature:
A factor of 10 reduction is 1 log (or 1 log10 reduction).
A 100-fold reduction is 2 logs (or 2 log10 reduction).
A 1000-fold reduction is 3 logs (or 3 log10 reduction).
3.7 logs (since log10(5000) ≈ 3.7)
In Percent:
A 5000-fold reduction means that for every 5000 units of viral RNA initially present, you now have 1 unit.
The percentage reduction can be calculated as:
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Added Sept. 29 2023:
2012 Ivermectin Inhibits Growth of Chlamydia trachomatis in Epithelial Cells
Here we show that ivermectin also inhibits infection of epithelial cells by the bacterial pathogen, Chlamydia trachomatis, at doses that could be envisioned clinically for sexually-transmitted or ocular infections by Chlamydia.
For use in humans as an anti-helminthic, ivermectin is typically received orally at a dose of 150 µg/kg body weight, and peak plasma concentrations from such dosage reach around 60 nM
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Added Sept. 29 2023:
1996 Ivermectin distribution in the plasma and tissues of patients infected with Onchocerca volvulus
The plasma levels for patients, after 5.2 hours, peaked at 52.0 ng/ml. The elimination half life was 35.0 h;
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Added Sept. 29 2023:
2023 Pharmacokinetics of ivermectin metabolites and their activity against Anopheles stephensi mosquitoes
Survival of malaria transmitting Anopheles mosquitoes is strongly decreased after feeding on humans recently treated with ivermectin. Currently, mass drug administration of ivermectin is under investigation as a potential novel malaria vector control tool to reduce Plasmodium transmission by mosquitoes. A "post-ivermectin effect" has also been reported, in which the survival of mosquitoes remains reduced even after ivermectin is no longer detectable in blood meals.
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Added Sept. 29 2023:
Ivermectin plasma concentration
Ivermectin’s impact on mosquito mortality is directly related to the time there is a lethal concentration in the blood
The longer the drug remains in the blood, the more mosquitoes it will kill or disable. Any increase in duration of mosquitocidal concentrations is expected to contribute to additional mortality. Modelling shows that the time the drug remains in blood above mosquito-killing levels is the parameter that drives impact on transmission [50].
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Added Sept. 29 2023:
Use of ivermectin for the management of scabies in a nursing home
Abstract:
Ivermectin was used for the treatment of a scabies outbreak in a nursing home. Among the 128 residents, 42 presented pruritus or cutaneous lesions and scabies was parasitologically demonstrated in seven patients. All residents were treated with two 12 mg doses of ivermectin given two weeks apart. Ivermectin treatment associated with procedures for environmental disinfection led to the control of the outbreak. In only one case, was there a failure of the treatment. It is concluded that oral ivermectin is an effective and practical therapy for scabies in nursing homes.
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Added Sept. 29 2023:
A five-day course of ivermectin may reduce the duration of COVID-19 illness
The highest dose of ivermectin that we have used in our study is 12 mg (200 µg/kg) once daily for 5 consecutive daysNote: This dose is calculated for a 133 pound person. , which resulted in a significantly shorter time for viral clearance. Viral clearance was earlier in the 5-day ivermectin treatment arm when compared with the placebo group (9.7 days vs 12.7 days; p = 0.02), but this was not the case for the ivermectin + doxycycline arm (11.5 days; p = 0.27). Similarly, clinical trials with a 3-day, once-daily dose of 400 µg/kg oral ivermectin in dengue patients has been shown to be safe, with accelerated clearance of the dengue virus nonstructural protein 1
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Added Sept. 29 2023:
Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment
FDA-approved anti-parasite drug ivermectin is also an antibacterial, antiviral, and anticancer agent, which offers more potentiality to improve global public health, and it can effectively inhibit the replication of SARtarget="_blank"S-CoV-2 in vitro
The findings in this study demonstrate the broad-spectrum antiviral property of ivermectin benefiting for COVID-19 treatment in the context of predictive, preventive, and personalized medicine in virus-related diseases.
Viruses mentioned:
HCMV Mayo HPV Mayo EBV VWH HIV-1 NIH
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Added Sept. 29 2023:
“Doctor, I have a Sulfa Allergy”: Clarifying the Myths of Cross-Reactivity
Sulfonamide antibiotic reactions encompass the entire spectrum of 4 types of hypersensitivity reactions.
Type 1 hypersensitivity is IgE-mediated and may include an anaphylactic sequelae. (Interpretation: Anaphylactic shock is possible.)
Type 2 reactions involve antibody-mediated cytotoxic cellular injury that may result in various cytopenias. (Interpretation: A soldier of your immune system targets an undesirable cell, then attacks it, glues itself to the enemy cell, then destroys it. Cytopenia means the attack is now destroying even your red blood cells.)
Type 3 and type 4 hypersensitivity results in the formation of antigen–antibody immune complexes or a delayed T cell-mediated reaction, respectively, either of which may progress to the life-threatening Stevens-Johnson syndrome or toxic epidermal necrolysis. (Interpretation: Your immune system goes into tornado mode and starts destroying anything that it thinks could possibly be an enemy cell, even to the point of killing the host body.)
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Added Sept. 29 2023:
Ivermectin-Clorsulon Overdose in Attempting Coronavirus Disease 2019 Prophylaxis: A Case Report
I believe the conclusion of this study should be challenged. Is it more likely this woman suffered an anaphlyactic response to the Clorsulon, possibly exacerbated by an eosinophil storm, described as a DRESS event?
My Question: Because Clorsulon is a sulfonamide, is it possible a hypersensitivity reaction was triggered?
Yes, because Clorsulon is a sulfonamide, it is possible that a hypersensitivity reaction could be triggered. Sulfonamide antibiotics are known to cause a variety of hypersensitivity reactions, ranging from benign rashes to severe cutaneous adverse reactions like Stevens-Johnson syndrome and toxic epidermal necrolysis. The potential for hypersensitivity reactions with sulfonamides is well-documented, with an incidence of adverse reactions in approximately 3% of the general population, and much higher in patients with conditions like HIV. While Clorsulon is primarily used as an antiparasitic agent, its sulfonamide structure means it shares common characteristics with sulfonamide antimicrobials, which could theoretically lead to cross-reactivity in individuals with a history of sulfonamide hypersensitivity. However, specific data on Clorsulon's hypersensitivity potential might be less extensive since it is not as widely used or studied as some other sulfonamide drugs.nih-1, sci-1
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Added Sept. 29 2023:
Ringworm-like skin lesion is not always tinea
Treatment with topical ivermectin 10 mg/g (1%) cream once daily resulted in an almost complete clinical resolution after 15 days [Figure - 4], but direct microscopy was still positive. Maintenance of the treatment for 2 months led to clinical and direct microscopic clearance at follow-up visit, with no relapses in the following 6 months.
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Added Sept. 29 2023:
Mechanisms of ivermectin-induced wound healing
Ivermectin promotes wound healing partly through modulation of the inflammatory process and the levels of Transforming Growth Factor-Beta 1 and Vascular Endothelial Growth Factor. Low doses of ivermectin cream have the potential to be used in treating wounds with minimal scar tissue formation.
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Added Sept. 29 2023:
IVERMECTIN ACTIVITY IN TREATMENT OF CATTLE DERMATOPYHTOSIS.
The aims of this study are to determine the prevalence of
cattle ringworm in native dairy farms of Diyala governorate, and the
distribution of T. verrucosum and treatment of the infection in the bovine by
ivermectin
Results: Statistical analysis reveals significantly less clearance time (50%) when ivermectin is used instead of topical antifungal 1% sulpher ointment in treating the disease. With less time of 13-24 days compared to 30-40 days. The treatment of ringworm disease in cattle with clearance rate of 100% is achieved using Ivermectin.
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Added Sept. 29 2023: Updated Oct. 02 2023
2021 Jan.: The broad spectrum host-directed agent ivermectin as an antiviral for SARS-CoV-2 ?
Ivermectin as a treatment for SARS-CoV-2 in humans has already been approved in a number of states and countries, including the Republic of Peru [44] and Northeastern Beni region of Bolivia [45]. Importantly, close to 70 trials worldwide are currently testing the clinical benefit of ivermectin to treat or prevent SARS-CoV-2 (see Table 3);
What does "host-directed" really mean? It means the therapy (in this case, Ivermectin) is directed at the host (you), in order to change the environment in which a virus in located. This makes the host an inhospitable place to live and inhibits its ability to replicate.
Starting in 2012, ivermectin’s antiviral properties have been progressively documented towards a number of RNA viruses, including human immunodeficiency virus (HIV)-1, influenza, flaviruses such as dengue and Zika, and most notably, SARS-CoV-2 (COVID-19)
4 ,
5 ,
7 ,
8 ,
9 ,
10 ,
11 ,
12 ,
13 ,
14 ,
15 ,
16 ,
17 ,
as well as DNA viruses such as pseudorabies, polyoma and adenoviruses
18 ,
19 ,
20
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Added Sept. 29 2023:
2016: Ivermectin induces PAK1-mediated cytostatic autophagy in breast cancer
Avermectin is a potent broad-spectrum parasiticidal drug, the discovery of which led to the award of the 2015 Nobel Prize in physiology or medicine. Its derivative, ivermectin, has recently been reported to be a potential anticancer agent against colon cancer, ovarian cancer, melanoma, and leukemia. Our recent study demonstrates that ivermectin also exerts a promising anticancer effect for breast cancer as evidenced by marked growth inhibition after 24-h treatment with ivermectin in a range of breast cancer cell lines, with no obvious effects on nontumorigenic human breast cells. The anticancer activity of ivermectin was further confirmed in both mouse subcutaneous xenografts and orthotopic breast cancer models.
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Added Sept. 29 2023:
2006 Mar.: A case of crusted scabies with a bullous pemphigoid-like eruption and nail involvement
Case Study: Patient was diagnosed as having crusted scabies with bullous pemphigoid-like eruptions and nail involvement
prescribed oral ivermectin (two doses of 12 mg ivermectin with a 1-week interval) and topical lindane (1%gamma-BHC in petrolatum) for scabies with 5% salicylic acid in plastibase as an additional treatment for the crusted lesions on his soles. He showed remarkable improvement in 2 weeks, and his nails showed complete recovery after 7 weeks of occlusive dressing treatment with 1%gamma-BHC.
The bullous symptoms of this patient were considered to be due to the scabies, because the patient recovered completely after receiving treatment for scabies. Indirect immunofluorescent study is important to distinguish between scabies with blister formation and true bullous pemphigoid.
Top
Added Sept. 30 2023:
2012 Oct.: Human viruses: discovery and emergence
There are 219 virus species that are known to be able to infect humans.
The first of these to be discovered was yellow fever virus in 1901, and three to four new species are still being found every year.
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Added Oct. 23 2023:
2019 Feb. New indications for topical ivermectin 1% cream: a case series study
Topical ivermectin is an effective treatment for inflammatory papulopustular rosacea in adults. Positive therapeutic effects of ivermectin due to its potential anti-inflammatory properties could be achieved in the other facial dermatoses.
In December 2014, the US Food and Drug Administration approved 1% ivermectin cream for treatment of rosacea in adults while the first European approval was obtained in March 2015.
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Added Nov. 26 2023:
Published: 01 September 2022 Integrated analysis reveals FOXA1 and Ku70/Ku80 as targets of ivermectin in prostate cancer
Herein, we report the pharmacological effects and targets of ivermectin in prostate cancer.
Recently, several studies have explored the potential of ivermectin as a new cancer treatment nih-2 ,nat-1 ,nat-2
In breast cancer, ivermectin decreases p21-activated kinase 1 (PAK1) expression by promoting its degradation and inducing cell autophagy [aacrj-1 ]
In ovarian cancer, ivermectin can block the cell cycle and induce cell apoptosis through a Karyopherin-β1 (KPNB1) related mechanism [pnas-1 ].
In leukemia, ivermectin preferentially kills leukemia cells at low concentrations by increasing the influx of chloride ions into cells, which triggers plasma membrane hyperpolarization and reactive oxygen species (ROS) production [cas-1 ]
. . .
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Added Mar. 24 2024:
FDA capitulates on some Ivermectin positions and comments
Retire FDA’s Consumer Update entitled, Why You Should Not Use
Ivermectin to Treat or Prevent COVID-19, originally posted on March 5,
2021, and revised on September 7, 2021 (ECF No. 12, Ex. 1), while
retaining the right to post a revised Consumer Update.
Delete and not republish
(1) FDA’s Twitter, LinkedIn, and Facebook posts from August 21, 2021 (ECF No. 12, Exs. 4, 5), that read, “You are not a horse. You are not a cow. Seriously, y’all. Stop it.”;
(2) FDA’s Instagram post from August 21, 2021 (ECF No. 12, Ex. 6), that reads, “You are not a horse. Stop it with the #ivermectin. It’s not authorized for treating #COVID.”
(3) FDA’s Twitter post from April 26, 2022 (ECF No. 12, Ex. 7), that reads, “Hold your horses, y’all. Ivermectin may be trending, but it still isn’t authorized or approved to treat COVID-19.”
(4) all other social media posts on FDA accounts that link to Why
You Should Not Use Ivermectin to Treat or Prevent COVID-19 (ECF No. 12,
Ex. 1) .
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Added Jul. 16 2024:
2024 June: Mosquitocidal effect of ivermectin-treated nettings and sprayed walls on Anopheles gambiae s.s.
Ivermectin (IVM) has been proposed as a new tool for malaria control as it is toxic on vectors feeding on treated humans or cattle.
IVM may have a direct mosquitocidal effect when applied on bed nets or sprayed walls.
The potential for IVM application as a new insecticide for long-lasting insecticidal nets (LLINs) and indoor residual spraying (IRS) was tested in this proof-of-concept study in a laboratory and semi-field environment.
The results showed a direct mosquitocidal effect of IVM on this mosquito strain as all mosquitoes died by 24 h after exposure to IVM.
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Added Oct. 13 2024:
Nov. 2023 IVERMECTIN - ivermectin tablet Edenbridge Pharmaceuticals LLC.
Subjects received oral doses of 30 to 120 mg (333 to 2000 mcg/kg) ivermectin in a fasted state or 30 mg (333 to 600 mcg/kg) ivermectin following a standard high-fat (48.6 g of fat) meal
Administration of 30 mg ivermectin following a high-fat meal resulted in an approximate 2.5-fold increase in bioavailability relative to administration of 30 mg ivermectin in the fasted state.
Significant lethality was observed in mice and rats after single oral doses of 25 to 50 mg/kg and 40 to 50 mg/kg, respectively. No significant lethality was observed in dogs after single oral doses of up to 10 mg/kgNote: These are more than 100 times the recommended dose.
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Added Oct. 17 2024:
Jan. 2014 Human Demodex Mite: The Versatile Mite of Dermatological Importance
After clinical manifestations (of demodex mites), the mites may be temporarily eradicated with topical insecticides, especially crotamiton cream, permethrin cream, and also with topical or systemic metronidazole. In severe cases, such as those with HIV infection, oral ivermectin may be recommended.
Colonization of the skin with Demodex could be a reflection of immune response of the host to organism.
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Added Nov. 14 2024:
Apr. 2021 Anthelmintics for drug repurposing: Opportunities and challenges
Drug repositioning( SD1 Drug repurposing (DR), also known as drug repositioning or re-profiling, is an approach to identify new therapeutic indications (other than original indications) of an already approved drug.
is defined as a process to identify a new application for drugs.
In 2018 there were 18.1 million new cancer cases. There were also 9.6 million cancer deaths that year.
The development of a new drug takes 10–15 years, and the success rate is negligible (approximately 2%).
There are seven classes of modern anthelmintics
Ivermectin, as a member of MLs, is metabolized in the liver by the cytochrome P450 system. The blood concentration of the drug reaches the peak 4 h after administration, and after that, the concentration decreases slowly. The metabolites concentration in the blood increases for a longer time when it is compared with the parent compound, which can be resulted from the heterohepatic recycling. The drug can be detected in various sites, including the nodules, and subcutaneous fascia. A single oral dose (12 mg) of ivermectin reaches the peak 8 h after administration in various sites, such as sebum, and forehead, and starts to decrease after 24 h
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Added Dec. 2 2024:
Dec. 2020 A five-day course of ivermectin for the treatment of COVID-19 may reduce the duration of illness
Ivermectin, a US Food and Drug Administration-approved anti-parasitic agent, was found to inhibit severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication in vitro.
A randomized, double-blind, placebo-controlled trial was conducted to determine the rapidity of viral clearance and safety of ivermectin among adult SARS-CoV-2 patients.
The trial included 72 hospitalized patients in Dhaka, Bangladesh, who were assigned to one of three groups:
Oral ivermectin alone (12 mg once daily12 mg once daily is considered the minimal effective prophylactic dose for a person who weighs 133 pounds (see the dosage calculator on this page).
Dosage Calculator
Oral ivermectin in combination with doxycycline (12 mg ivermectin single dose and 200 mg doxycycline on day 1, followed by 100 mg every 12 h for the next 4 days)
A placebo control group.
Clinical symptoms of fever, cough, and sore throat were comparable among the three groups.
Virological clearance was earlier in the 5-day ivermectin treatment arm when compared to the placebo group (9.7 days vs 12.7 days; p = 0.02), but this was not the case for the ivermectin + doxycycline arm (11.5 days; p = 0.27).
There were no severe adverse drug events recorded in the study.
A 5-day course of ivermectin was found to be safe and effective in treating adult patients with mild COVID-19.
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Added Dec. 16 2024:
2021 May 14; Ivermectin effectively inhibits hepatitis E virus replication, requiring the host nuclear transport protein importin α1
Ivermectin, an FDA-approved anti-parasitic drug, effectively inhibits infection with hepatitis E virus (HEV) genotypes 1 and 3 in a range of cell culture models, including hepatic and extrahepatic cells.
Long-term treatment showed no clear evidence of the development of drug resistance.
Gene silencing of importin-α1, a cellular target of ivermectin and a key member of the host nuclear transport complex, inhibited viral replication and largely abolished the anti-HEV effect of ivermectin. What does this mean?The statement indicates that importin-α1 is vital for HEV replication. Ivermectin targets this protein to inhibit viral replication. However, if importin-α1 is silenced (its expression is reduced or eliminated), HEV replication decreases, but so does ivermectin's ability to fight the virus because it can no longer interact with this key protein in its mechanism of action.
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Added Dec. 16 2024:
2012 Apr 25; Ivermectin is a potent inhibitor of flavivirus replication specifically targeting NS3 helicase activity: new prospects for an old drug
Infection with yellow fever virus (YFV), the prototypic mosquito-borne flavivirus, causes severe febrile disease with haemorrhage, multi-organ failure and a high mortality.
Ivermectin, a broadly used anti-helminthic drug, proved to be a highly potent inhibitor of YFV replication (EC50 values in the sub-nanomolar range).
Moreover, ivermectin inhibited, although less efficiently, the replication of several other flaviviruses, i.e. dengue fever, Japanese encephalitis and tick-borne encephalitis viruses.
Considering that this well tolerated drug has been licensed for >20years for the treatment of parasitic infections in man, our results provide the prospect of the first specific anti-flavivirus therapy by the off-label use of ivermectin (patent application EP2010/065880).
My Comment Added Dec. 16 2024:
Ivermectin has not been approved by the FDA for use on flaviviruses. Ivermectin is FDA-approved for certain parasitic infections in humans, including strongyloidiasis and onchocerciasis, and for various external parasites like head lice when used topically. However, it has not received FDA approval for treating or preventing infections caused by flaviviruses, which include viruses like Dengue, Yellow Fever, West Nile, and Zika.
Several studies have explored ivermectin's potential antiviral effects against flaviviruses:
In vitro studies have shown that ivermectin can inhibit the replication of flaviviruses like Dengue, Yellow Fever, and West Nile by specifically targeting their NS3 helicase activity, suggesting potential antiviral effects.
Despite these findings, there's a lack of clinical data supporting ivermectin's efficacy against flaviviruses in human patients, and the FDA has not authorized or approved ivermectin for this use.
The discussion around ivermectin's use for various viral infections, including those by flaviviruses, remains largely in the realm of research and has not transitioned to FDA-approved applications for these purposes. The FDA's stance on ivermectin primarily relates to its use in parasitic infections, not viral ones, and any off-label use would not constitute formal FDA approval.