Research Regarding Vitamin C and Prostate Cancer Management

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I'm providing this tool, because it eliminates a lot of the SPOAFStating Personal Opinion As Fact websites that are popping up, and are filled with ads, and are just there to make money off the ads.

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• site:nih.gov intravenous vitamin c elimination rate

Quick Summaries

• ¹Calculating a target maintainable plasma concentration.
• ²Repurposed Drugs and Metabolic Interventions In Treating Cancer

Comments & Notes

Quick Summaries

Abbreviations

References:

1. ^{Top Return}

   Added May 17 2024:

   2015 Apr; Elimination of ascorbic acid after high-dose infusion in prostate cancer patients: a pharmacokinetic evaluation

   • Purpose of this study was to assess the basic kinetic variables in human beings over a relevant AA dosing interval for proper design of future clinical trials.
   • Ten patients with metastatic prostate cancer were treated for 4 weeks with fixed AA doses of 5, 30 and 60 g.
   • The target dose of 60 g AA IV produced a peak plasma AA concentration of 20.3 mM.
   • Elimination half-life was 1.87 hr (mean, S.D. ± 0.40), volume of distribution 0.19 L/kg (S.D. ±0.05) and clearance rate 6.02 L/hr (100 mL/min).
   • No differences in pharmacokinetic parameters were observed between weeks/doses.
   • A relatively fast first-order elimination with half-life of about 2 hr makes it impossible to maintain AA concentrations in the potential cytotoxic range after infusion stop in prostate cancer patients with normal kidney function.
   • Full text of study (free)
2. ^TopReturn

   Added December 1, 2024:

   2024 Oct.; Cancer Care The Role of Repurposed Drugs and Metabolic Interventions In Treating Cancer 2nd Edition

   • This is a PDF download
   • Chapter 1: Introduction
   • Chapter 2: What is cancer: understanding its pathogenetic causes
   • Chapter 3: Preventing cancer
   • Chapter 4: The metabolic approach to treating cancer
   • Glucose management and the ketogenic diet
   • Chapter 5: Metabolic and lifestyle interventions for cancer treatment
   • Chapter 6: Repurposed drugs
   • Chapter 7: Tier one repurposed drugs – strong recommendation
   • Chapter 8: Tier two repurposed drugs – weak recommendation
   • Chapter 9: Tier three repurposed drugs -insuficient data
   • Chapter 10: Tier four repurposed drugs – recommend against
   • Chapter 11: Potential adjunctive therapies
   • Chapter 12: Chemotherapy: a basic primer
3. TopReturn

   Added December 4, 2024:

   2022 Oct.; High dose intravenous vitamin c treatment in a patient with lung cancer: A case report

   • A 56-year-old Hispanic male patient diagnosed with lung cancer. After undergoing surgery and chemotherapy, he started a high dose intravenous Vitamin C protocol
   • A maximum of 75 gr of Vitamin C in 1,000 cc lactated Ringer’s was given three times a week in a period over a year and a half.
   • CEACarcinoembryonic antigen (CEA) is a protein that can be found in the blood and is used as a tumor marker to help monitor cancer treatment and recurrence:^CC-1 levels continued to be within normal levels while high doses of Vitamin C infusions were given.
   • It has been reported that a vitamin C plasma level above 400 mg/dL is toxic to tumor cells^PRHSJ-1